![]() ![]() In comparison, peripheral neural function was relatively intact. The results suggest poor myelination and synaptic function of the brainstem in infants with bronchopulmonary dysplasia, resulting in impaired functional integrity. The slope of the III-V/I-III interval ratio-rate function for the infants with bronchopulmonary dysplasia was also significantly steeper than those for the 2 control groups. To obtain an estimated neonatal risk that is not necessarily directly related to brainstem compromise, infants’ neonatal medical risk was assessed using the Clinical Risk Index for Babies (CRIB) ( CRIB and International Neonatal Network, 1993 ). is considered to reflect brain function of the infant and is widely used to. The slopes of the wave V latency-rate function and I-V and particularly III-V interval-rate functions for the infants with bronchopulmonary dysplasia were significantly steeper than those for both term and healthy, very preterm control subjects. Background: Breast milk is important for brain development as it contains. The wave I and III latencies and I-III interval in the infants with bronchopulmonary dysplasia did not show any abnormalities. Compared with healthy, very preterm control subjects, all of these maximal length sequence brainstem auditory evoked response variables increased significantly at all click rates, although the differences between the 2 groups were slightly smaller than those between the infants with bronchopulmonary dysplasia and the term control subjects. All of these abnormalities became more significant as the click rate was increased. The III-V/I-III interval ratio also increased significantly at all click rates. Similarly, I-V and particularly III-V interpeak intervals increased significantly. These changes influence the vulnerability of the immature brain to injury as well as mechanisms of recovery that are engaged after injury. ![]() The brain stem is made of the midbrain, pons, and medulla. Brainstem auditory evoked responses were recorded and analyzed by using the maximal length sequence technique.Ĭompared with term control subjects, wave V latency in the maximal length sequence brainstem auditory evoked response of the infants with bronchopulmonary dysplasia increased significantly at all 91 to 910 clicks per second rates. The immature brain, however, is a dynamic environment with significant changes to cellular composition, neural circuitry, and blood flow occurring throughout childhood 1. The lowest part of the brainstem, the medulla is the most vital part of the entire brain and contains important control centers for the heart and lungs. It is responsible for vital life functions such as breathing, heartbeat, and blood pressure. ![]() To gain new insights into the influence of bronchopulmonary dysplasia on the immature brain and to detect abnormalities, we studied the functional integrity of the brainstem in infants with bronchopulmonary dysplasia.įorty-one very preterm infants with bronchopulmonary dysplasia were studied at postconceptional ages of 37 to 42 weeks. ![]()
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